Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity

JK Luo; H Melland; J Nithianantharajah; SL Gordon

Journal article

Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity

JK Luo, H Melland, J Nithianantharajah, SL Gordon

Frontiers in Molecular Neuroscience | FRONTIERS MEDIA SA | Published : 2021

DOI: 10.3389/fnmol.2021.744845

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Abstract

Fast, high-fidelity neurotransmission and synaptic efficacy requires tightly regulated coordination of pre- and postsynaptic compartments and alignment of presynaptic release sites with postsynaptic receptor nanodomains. Neuroligin-1 (Nlgn1) is a postsynaptic cell-adhesion protein exclusively localised to excitatory synapses that is crucial for coordinating the transsynaptic alignment of presynaptic release sites with postsynaptic AMPA receptors as well as postsynaptic transmission and plasticity. However, little is understood about whether the postsynaptic machinery can mediate the molecular architecture and activity of the presynaptic nerve terminal, and thus it remains unclear whether the..

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University of Melbourne Researchers

Jess Nithianantharajah Author

Sarah Gordon Author

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Grants

Awarded by State Government of Victoria

Funding Acknowledgements

Funding This work was supported by an Australian Research Council Future Fellowship (FT140101327) to JN, a National Health and Medical Research Council of Australia Career Development Fellowship (GNT1105478) and Florey Fellowship to SG, an Australian Government Research Training Program Scholarship to JL and HM, and National Health and Medical Research Council of Australia Project Grants to JN (GNT1083334 and GNT1163504) and SG (GNT1085483 and GNT2003710). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.